The world’s only interactive bioinformatics technology for functional and taxonomic whole genome shotgun metagenomics analysis and visualization.
MEGAN Metagenomics Analysis Software allows visual and quantitative exploration of microbiomes on a desktop computer. Your data is simultaneously annotated for taxonomic and functional composition to a wide range of databases. MEGAN6 Ultimate Edition (MEGAN6 UE) contains many features beyond the MEGAN6 Community Edition, including an up-to-date version of the KEGG pathway database. MEGAN6 UE was developed by our co-founder Professor Daniel Huson. Request a MEGAN6 UE 30-day trial license today!
Includes an up-to-date version of KEGG, the most comprehensive biochemical pathway database. Harness the power of this database without having to perform additional analysis steps, right after importing your alignments.
Our award-winning weighted Lowest Common Ancestor (LCA) algorithm makes taxonomic classification more precise than any alternative approach.
Intuitively develop scripts of your analysis workflows based on the commands displayed in the message window while performing your interactive analysis.
Compare taxon abundance over the whole NCBI taxonomy tree, automatically recompute abundance data for the taxonomic rank of interest. Easily do the same for KEGG Pathways and individual pathway maps.
The samples viewer is a powerful tool for managing your samples. Add study metadata like information treatment group or time point, subset your data or remove samples with ease. Use the metadata to sort or color your samples and perform comparisons with ease.
Make your analyses reproducible by building workflows that perform the same tasks for multiple studies. MEGAN also contains command-line tools to convert from and to other popular metagenomics file formats.
MEGAN is designed to work with alignments generated by DIAMOND, the ultrafast DARPA challenge winning aligner that is up to 10,000x faster than BLAST. Import DIAMOND Alignment Archives (DAA) directly and efficiently without additional conversion steps. LCA
Visualizations are key in understanding your metagenomics project. MEGAN includes many powerful visualizations such as heat maps, radial space filling trees, co-occurence plots, attribute correlation plots, stacked bar charts, and word clouds.
Improve the annotation of your metagenomes by adding your internal sequence databases and mapping files using the Ultimate Edition exclusive tools for database customization.
 |
 |
|
|---|---|---|
| Download Links | Community Edition Latest Version | Ultimate Edition Latest Version |
| Databases, Ontologies, Resources | Taxonomy (NCBI, GTDB) InterPro2GO eggNOG |
Taxonomy (NCBI, GTDB) InterPro2GO eggNOG KEGG (updated twice per year) SEED RDP |
| Plots: a few examples | Bar Pie Line Stacked Word clouds |
Bar Pie Line Stacked Word clouds Radial space filling trees Attribute correlation plot True 3D PCoA viewer (MacOS and Windows only) Parallel coordinates viewer … Constantly adding new ones, submit your request |
| Command-Line Tools and Utilities | Blast2RMA DAA Meganizer |
Blast2RMA DAA Meganizer NCBI taxonomy tools InterPro2Go tools eggNOG tools KEGG tools SEED tools SILVA tools |
| Miscellaneous | No scripting Basic MEGAN server |
Full scripting capability Enhanced MEGAN Server with project and user management, and data download functionality SQLite database export |
| Extensions | Community-generated | Latest KEGG classification and pathways (KEGG License included) Computomics-provided Extensions (custom built) Community-generated |
| Updates | Occasional bug fixes No new features |
Regular bug fixes All new features as they are added |
| Support | MEGAN Community page | MEGAN Community page Email support Questions answered by developers Service and assistance packages available |
| Licensing | GPL 3 | Licensed by Computomics |
